Lethality of Candida strains as influenced by the host

Can J Microbiol. 1975 May;21(5):648-54. doi: 10.1139/m75-093.

Abstract

A comparative study of the pathogenicity of Candida albicans morphological mutant strains was made to relate chlamydospore production, germ tube formation, and proteolytic activity to candidiasis in mice. It was observed that the mycelium strains were more lethal than the yeast-like strains and that neither chlamydospore production, germ tube formation, nor nutritional resquirements was related to pathogenicity in mice. Statistical analysis indicated that the culture media of the organisms and the strain and sex of the mice into which the cells were injected were important in the development of pathogenicity.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Candida albicans / growth & development
  • Candida albicans / metabolism
  • Candida albicans / pathogenicity*
  • Candidiasis / mortality*
  • Female
  • Male
  • Mice
  • Mice, Inbred DBA
  • Mutation
  • Peptide Hydrolases / biosynthesis
  • Species Specificity
  • Virulence

Substances

  • Peptide Hydrolases