Type IV collagen as an early marker for diabetic nephropathy in non-insulin-dependent diabetes mellitus

J Diabetes Complications. Jan-Feb 2000;14(1):13-7. doi: 10.1016/s1056-8727(00)00064-7.


We measured urinary albumin (U-Alb) and type IV collagen (uIV.C) in spot urine collected from 82 patients with non-insulin-dependent diabetes mellitus (NIDDM) and 205 controls. Eighty-two NIDDM patients that had no increased excretion of either U-Alb or uIV.C were observed for 6 months. Prevalence of increased excretion of U-Alb and uIV.C at 6 months in these patients were 32.9%, and 62.2%, respectively. Increased excretion of uIV.C was detected in 27 patients without microalbuminuria. chi(2) analysis suggested that uIV.C was more sensitive than U-Alb, and that hypertension enhanced increased excretion of both U-Alb and uIV.C. uIV.C was significantly correlated (P<0.01) with U-Alb but not glycosylated hemoglobin A1C (HbA1C) in NIDDM patients. Taken together, uIV.C may be a useful marker for early diabetic nephropathy.

MeSH terms

  • Adult
  • Aged
  • Albuminuria / urine
  • Biomarkers / urine*
  • Collagen / urine*
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / therapy
  • Diabetes Mellitus, Type 2 / urine*
  • Diabetic Nephropathies / urine*
  • Female
  • Glycated Hemoglobin A / analysis
  • Humans
  • Hypertension / drug therapy
  • Hypertension / urine
  • Male
  • Middle Aged


  • Biomarkers
  • Glycated Hemoglobin A
  • Collagen