Epithelial calcium channel: gate-keeper of active calcium reabsorption

Curr Opin Nephrol Hypertens. 2000 Jul;9(4):335-40. doi: 10.1097/00041552-200007000-00003.


The epithelial calcium channel present in the apical membrane of 1,25-dihydroxyvitamin D3-responsive nephron segments represents the first member of a new family of calcium channels. This review covers the distinctive properties of this highly calcium-selective channel and highlights the implications for our understanding of the process of calcium reabsorption.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Calcium / metabolism*
  • Calcium Channels / chemistry
  • Calcium Channels / genetics
  • Calcium Channels / physiology*
  • Humans
  • Kidney / physiology*
  • Molecular Sequence Data
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Urothelium / physiology*


  • Calcium Channels
  • Calcium