The effects of acid on bone

Curr Opin Nephrol Hypertens. 2000 Jul;9(4):369-79. doi: 10.1097/00041552-200007000-00008.


Metabolic acidosis induces calcium efflux from bone and in the process buffers the additional hydrogen ions. Initially metabolic acidosis stimulates physicochemical mineral dissolution and then cell-mediated bone resorption. Acidosis increases activity of the bone resorbing cells, the osteoclasts, and decreases activity of the bone forming cells, the osteoblasts. Osteoblastic immediate early response genes are inhibited as are genes controlling matrix formation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acidosis / physiopathology*
  • Animals
  • Bone Resorption / etiology
  • Bone Resorption / physiopathology*
  • Bone and Bones / physiology
  • Bone and Bones / physiopathology*
  • Carbonates / metabolism
  • Gene Expression Regulation / physiology
  • Humans
  • Osteoblasts / physiology
  • Osteoclasts / physiology


  • Carbonates