Hepatocyte growth factor in renal regeneration, renal disease and potential therapeutics

Curr Opin Nephrol Hypertens. 2000 Jul;9(4):395-402. doi: 10.1097/00041552-200007000-00011.

Abstract

Hepatocyte growth factor (HGF) has mitogenic, motogenic, morphogenic, and anti-apoptotic activities on renal cells and is a potential renotropin for renal protection and repair. In chronic renal failure/fibrosis, HGF in the kidney declines in a reciprocal manner to the increase in transforming growth factor-beta (TGF-beta). Neutralization of HGF by the antibody leads to acceleration of renal failure/fibrosis while HGF administration leads to remarkable attenuation, thus indicating the importance of HGF versus TGF-beta counterbalance in both pathogenesis and therapeutics in cases of chronic renal failure. HGF is being strongly considered for potential treatment of acute and chronic renal failure.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Hepatocyte Growth Factor / physiology*
  • Humans
  • Kidney / physiology*
  • Kidney / physiopathology
  • Kidney Diseases / physiopathology*
  • Kidney Diseases / therapy
  • Kidney Failure, Chronic / physiopathology
  • Kidney Failure, Chronic / therapy
  • Regeneration / physiology*
  • Transforming Growth Factor beta / physiology

Substances

  • Transforming Growth Factor beta
  • Hepatocyte Growth Factor