Effects of short-term oral salbutamol administration on exercise endurance and metabolism

J Appl Physiol (1985). 2000 Aug;89(2):430-6. doi: 10.1152/jappl.2000.89.2.430.


The present study examined whether oral short-term administration of salbutamol (Sal) modifies performance and selected hormonal and metabolic variables during submaximal exercise. Eight recreational male athletes completed two cycling trials at 80-85% peak O(2) consumption until exhaustion after either gelatin placebo (Pla) or oral Sal (12 mg/day for 3 wk) treatment, according to a double-blind and randomized protocol. Blood samples were collected at rest, after 5, 10, and 15 min, and at exhaustion to determine growth hormone (GH), cortisol, testosterone, triiodothyronine (T(3)), C peptide, free fatty acid (FFA), blood glucose, lactate, and blood urea values. Time of cycling was significantly increased after chronic Sal intake (Sal: 30.5 +/- 3.1 vs. Pla: 23.7 +/- 1.6 min, P < 0.05). No change in any variable was found before cycling except a decrease in blood urea concentration and an increase in T(3) after Sal that remained significant throughout the exercise test (P < 0.05). Compared with rest, exercise resulted in a significant increase in GH, cortisol, testosterone, T(3), FFAs, and lactate and a decrease in C peptide after both treatments with higher exercise FFA levels and exhaustion GH concentrations after Sal (P < 0.05). Sal but not Pla significantly decreased exercise blood glucose levels. From these data, short-term Sal intake did appear to improve performance during intense submaximal exercise with concomitant increase in substrate availability and utilization, but the exact mechanisms involved need further investigation.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adrenergic beta-Agonists / pharmacology*
  • Adult
  • Albuterol / pharmacology*
  • Blood Glucose / metabolism
  • Blood Urea Nitrogen
  • Cross-Over Studies
  • Double-Blind Method
  • Exercise / physiology*
  • Fatty Acids, Nonesterified / blood
  • Hormones / blood
  • Humans
  • Lactic Acid / blood
  • Male
  • Metabolism / drug effects*
  • Physical Endurance / drug effects*


  • Adrenergic beta-Agonists
  • Blood Glucose
  • Fatty Acids, Nonesterified
  • Hormones
  • Lactic Acid
  • Albuterol