Nd:YAG laser corneal disruption as adjuvant treatment for infectious crystalline keratopathy

Am J Ophthalmol. 2000 Jun;129(6):800-1. doi: 10.1016/s0002-9394(00)00468-2.


Purpose: To report on the use of the Nd:YAG laser corneal disruption in the treatment of infectious crystalline keratopathy.

Method: Case report. A 52-year-old woman with infectious crystalline keratopathy unresponsive to topical antibiotics was treated with an Nd:YAG laser to the intrastromal crystals.

Results: After Nd:YAG laser treatment, the infiltrate completely cleared within 4 weeks.

Conclusions: Nd:YAG laser treatment may be effective in disrupting the protective glycocalyx matrix within the intrastromal crystals, rendering the bacteria susceptible to topical antibiotics. This treatment should be considered for patients with infectious crystalline keratopathy clinically resistant to topical antibiotics.

Publication types

  • Case Reports

MeSH terms

  • Biofilms / drug effects
  • Cefazolin / therapeutic use
  • Cephalosporins / therapeutic use
  • Chemotherapy, Adjuvant
  • Corneal Diseases / drug therapy
  • Corneal Diseases / microbiology
  • Corneal Diseases / surgery*
  • Corneal Stroma / drug effects
  • Corneal Stroma / microbiology
  • Corneal Stroma / surgery*
  • Eye Infections, Bacterial / drug therapy
  • Eye Infections, Bacterial / microbiology
  • Eye Infections, Bacterial / surgery*
  • Female
  • Humans
  • Laser Coagulation*
  • Middle Aged
  • Streptococcal Infections / drug therapy
  • Streptococcal Infections / microbiology
  • Streptococcal Infections / surgery*
  • Streptococcus / drug effects
  • Streptococcus / isolation & purification


  • Cephalosporins
  • Cefazolin