Aspergillus flavus keratitis after laser in situ keratomileusis

Am J Ophthalmol. 2000 Jun;129(6):802-4. doi: 10.1016/s0002-9394(00)00406-2.


Purpose: To report a case of fungal keratitis caused by Aspergillus flavus after laser in situ keratomileusis surgery.

Methods: Case report. A 24-year-old woman developed pain, redness, decreased vision, and an infiltrate posterior to the corneal flap in her right eye 3 days after laser in situ keratomileusis. On referral, approximately 3 weeks after laser in situ keratomileusis, examination of the right eye revealed light perception vision, a large full-thickness corneal infiltrate, and hypopyon. Corneal scrapings were taken for direct microscopic examination and culture.

Results: Corneal scraping revealed the presence of fungal filaments in smears and in culture. The fungus was identified as A. flavus. Intensive topical natamycin and systemic ketoconazole therapy was initiated. Despite intensive medical treatment, the infiltrate progressed and the patient was subjected to a therapeutic penetrating keratoplasty. There was no recurrence of infection after surgery. At last follow-up 4 months after surgery, the eye was quiet with graft edema.

Conclusion: Fungal keratitis is a rare complication of laser in situ keratomileusis surgery. In a case that does not respond to medical treatment, early surgical intervention must be considered.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antifungal Agents / therapeutic use
  • Aspergillosis / etiology*
  • Aspergillosis / microbiology
  • Aspergillosis / therapy
  • Aspergillus flavus / isolation & purification*
  • Cornea / microbiology
  • Eye Infections, Fungal / etiology*
  • Eye Infections, Fungal / microbiology
  • Eye Infections, Fungal / therapy
  • Female
  • Humans
  • Keratitis / etiology*
  • Keratitis / microbiology
  • Keratitis / therapy
  • Keratomileusis, Laser In Situ / adverse effects*
  • Keratoplasty, Penetrating


  • Antifungal Agents