Rhegmatogenous retinal detachment in retinoblastoma patients undergoing chemoreduction and cryotherapy

Am J Ophthalmol. 2000 Jun;129(6):817-9. doi: 10.1016/s0002-9394(00)00407-4.


Purpose: To report the development of rhegmatogenous retinal detachment, with the retinal break adjacent to a cryotherapy scar, in three patients undergoing systemic chemotherapy for intraocular retinoblastoma.

Method: Case series.

Results: Three patients with intraocular retinoblastoma were referred after poor response to systemic chemotherapy and local cryotherapy; three eyes of these three patients were noted to have rhegmatogenous retinal detachment and active retinoblastoma, with retinal breaks adjacent to cryotherapy scars.

Conclusion: Rhegmatogenous retinal detachment may result from retinal necrosis associated with cryotherapy in the setting of intraocular retinoblastoma treated with systemic chemotherapy and local cryotherapy.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Child, Preschool
  • Combined Modality Therapy
  • Cryotherapy / adverse effects*
  • Eye Enucleation
  • Female
  • Humans
  • Infant
  • Male
  • Retinal Detachment / diagnostic imaging
  • Retinal Detachment / etiology*
  • Retinal Detachment / surgery
  • Retinal Neoplasms / therapy*
  • Retinal Perforations / diagnostic imaging
  • Retinal Perforations / etiology
  • Retinal Perforations / surgery
  • Retinoblastoma / therapy*
  • Ultrasonography