Inhibition of luteinizing hormone secretion induced by synthetic LRH by long-term treatment with glucocorticoids in human subjects

J Clin Endocrinol Metab. 1975 May;40(5):774-9. doi: 10.1210/jcem-40-5-774.


The response of luteinizing hormone to a single injection of synthetic LRH was established in 6 women and 7 men following an intramuscular dose of 0.2mg or 0.1mg. Significant increases of serum LH were observed in 30 min. Pretreatment with metyrapone for one day (4.5 g/sugject injection of synthetic LRH (0.1 MG/SUBJECT). Seven women, 21-48 years of age who were treated with prednisolone for a least 11/2 months were examined for responsiveness of the anterior pituitary to a single injection of synthetic LRH (0.2 MG). The secretion of LH was markedly suppressed and maximal serum levels of LH WERE OBSERVED 90 MIN FOLLOWING LRH injection.

MeSH terms

  • Adult
  • Female
  • Gonadotropin-Releasing Hormone / chemical synthesis
  • Gonadotropin-Releasing Hormone / pharmacology*
  • Humans
  • Luteinizing Hormone / blood
  • Luteinizing Hormone / metabolism*
  • Male
  • Metyrapone / pharmacology*
  • Pituitary Gland / drug effects
  • Pituitary Gland / metabolism*
  • Prednisolone / pharmacology*
  • Sex Factors
  • Time Factors


  • Gonadotropin-Releasing Hormone
  • Luteinizing Hormone
  • Prednisolone
  • Metyrapone