Biological chemistry and clinical potential of S-nitrosothiols

Free Radic Biol Med. 2000 May 15;28(10):1478-86. doi: 10.1016/s0891-5849(00)00248-3.

Abstract

S-Nitrosothiols are endogenous metabolites of nitric oxide that have been detected in extra- and intracellular spaces. Many biological functions of S-nitrosothiols have been described that can be categorized as being due to one or more of the following: (i) nitric oxide release, (ii) transnitrosation, (iii) S-thiolation, and (iv) direct action. This emphasizes the fact that S-nitrosothiols are more than simply nitric oxide donors. Many of the biological functions that have been described for S-nitrosothiols have clinical correlates. This review describes the biological chemistry, biological actions, and clinical potential of these compounds.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Drug Stability
  • Glutathione / analogs & derivatives
  • Glutathione / pharmacology
  • Humans
  • Mercaptoethanol*
  • Nitric Oxide Donors / chemical synthesis
  • Nitric Oxide Donors / chemistry
  • Nitric Oxide Donors / pharmacology
  • Nitroso Compounds / chemistry*
  • Nitroso Compounds / metabolism
  • Nitroso Compounds / pharmacology*
  • Penicillamine / analogs & derivatives
  • Penicillamine / pharmacology
  • Platelet Aggregation Inhibitors / pharmacology
  • S-Nitrosoglutathione
  • S-Nitrosothiols*

Substances

  • Nitric Oxide Donors
  • Nitroso Compounds
  • Platelet Aggregation Inhibitors
  • S-Nitrosothiols
  • S-nitro-N-acetylpenicillamine
  • S-Nitrosoglutathione
  • Mercaptoethanol
  • S-nitrosomercaptoethanol
  • Glutathione
  • Penicillamine