Evaluation of migraineurs' preferences for naratriptan over conventional first-line agents

Arch Fam Med. 2000 Aug;9(8):753-8. doi: 10.1001/archfami.9.8.753.


Objective: To assess patient satisfaction with and preference for naratriptan hydrochloride therapy over previous "nontriptan" therapy for migraines.

Design and setting: Open-label study conducted at 15 primary care clinics.

Patients: One hundred forty-three adults meeting International Headache Society diagnostic criteria for migraine who were not using triptans as first-line therapy for migraines were enrolled; 115 completed the study. INTERVENTION AND OUTCOME ASSESSMENTS: At baseline, satisfaction with current migraine therapy was assessed. Patients were provided with naratriptan hydrochloride, 2.5 mg, to treat 3 migraines and diaries to record headache symptoms and response to treatment. After treating 3 migraines, satisfaction with naratriptan therapy and preference for either previous or naratriptan therapy were assessed.

Results: Eighty-nine (62%) of 143 patients had previous exposure to triptans, with lack of prescribing (55%) as the primary reason for not continuing their use as first-line therapy. Medications used for first-line therapy included simple analgesics (59%), combination products (46%), and narcotics (13%). After treating 3 migraines with naratriptan, satisfaction with migraine therapy increased from 47% to 75%. Sixty-three percent of patients preferred naratriptan therapy over their previous nontriptan therapy, 27% preferred their previous therapy, and 10% had no preference. The main reasons for preference for naratriptan therapy were "relieves pain effectively" (86%) and "restores ability to function/perform task" (81%).

Conclusion: Naratriptan for first-line migraine therapy was preferred by most patients over previous nontriptan therapy.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Female
  • Humans
  • Indoles / therapeutic use*
  • Male
  • Middle Aged
  • Migraine Disorders / drug therapy*
  • Patient Satisfaction / statistics & numerical data
  • Piperidines / therapeutic use*
  • Serotonin Receptor Agonists / therapeutic use
  • Treatment Outcome
  • Tryptamines
  • Vasoconstrictor Agents / therapeutic use*


  • Indoles
  • Piperidines
  • Serotonin Receptor Agonists
  • Tryptamines
  • Vasoconstrictor Agents
  • naratriptan