Apnea of prematurity. Comparative therapeutic effects of cutaneous stimulation and nasal continuous positive airway pressure

J Pediatr. 1975 Apr;86(4):588-92. doi: 10.1016/s0022-3476(75)80158-2.


It has been suggested that idiopathic apnea of prematurity is related to hypoxia from pulmonary instability or an immaturity of central respiratory control mechanisms. To explore these hypotheses, 18 preterm infants were studied to examine the therapeutic effects of prophylactic cutaneous stimulation (6) and continuous positive airway pressure(12). The frequency of apnea using each procedure was reduced by 35 and 69 percent, respectively. These findings constitute the basis for new therapeutic measures for treatment of idiopathic neonatal apnea.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Apnea / therapy*
  • Birth Weight
  • Cyanosis / therapy
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Infant, Premature, Diseases / therapy*
  • Physical Stimulation / methods*
  • Positive-Pressure Respiration / methods*
  • Touch