Molecular mechanisms of radiation carcinogenesis and the linear, non-threshold dose response model of radiation risk estimation

Radiat Environ Biophys. 2000 Jun;39(2):79-87. doi: 10.1007/s004110000047.


Recent research in molecular radiation carcinogenesis is reviewed with the specific aim of exploring the implications this research may have on the dose response relationship of radiation-induced cancer at low doses and low dose rates. It is concluded that the linear non-threshold dose response hypothesis may be used in radiation protection planning as a simple, convenient method to optimize procedures and regulations, but should not be mistaken as a stringent scientific conclusion directly derived from the present state of knowledge of the processes involved in radiation carcinogenesis.

Publication types

  • Review

MeSH terms

  • DNA Repair
  • Dose-Response Relationship, Radiation*
  • Genes, Tumor Suppressor / genetics
  • Genetic Predisposition to Disease
  • Humans
  • Linear Models
  • Models, Biological
  • Neoplasms, Radiation-Induced / epidemiology
  • Neoplasms, Radiation-Induced / genetics*
  • Neoplasms, Radiation-Induced / metabolism*
  • Selection, Genetic