Interactions Between Insulin Resistance and Insulin Secretion in the Development of Glucose Intolerance

J Clin Invest. 2000 Aug;106(3):329-33. doi: 10.1172/JCI10761.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 2 / etiology
  • Diabetes Mellitus, Type 2 / physiopathology
  • Fatty Acids, Nonesterified / physiology
  • Gene Expression
  • Glucose Intolerance / etiology
  • Glucose Intolerance / genetics
  • Glucose Intolerance / physiopathology*
  • Humans
  • Insulin / metabolism*
  • Insulin Resistance / genetics
  • Insulin Resistance / physiology*
  • Insulin Secretion
  • Islets of Langerhans / metabolism
  • Islets of Langerhans / physiopathology
  • Mice

Substances

  • Fatty Acids, Nonesterified
  • Insulin