Gluten-dependent Diabetes-Related and Thyroid-Related Autoantibodies in Patients With Celiac Disease

J Pediatr. 2000 Aug;137(2):263-5. doi: 10.1067/mpd.2000.107160.

Abstract

Patients with celiac disease are at high risk of having autoimmune disorders. Moreover, untreated patients with celiac disease have been found to have a higher than expected prevalence of organ-specific autoantibodies. In a prospective study of 90 patients with celiac disease, we found that the prevalence of diabetes and thyroid-related serum antibodies was 11.1% and 14.4%, respectively. Like antiendomysium autoantibodies, these organ-specific antibodies seem to be gluten-dependent and tend to disappear during a gluten-free diet.

MeSH terms

  • Case-Control Studies
  • Celiac Disease / diet therapy
  • Celiac Disease / epidemiology*
  • Child
  • Comorbidity
  • Diabetes Mellitus, Type 1 / epidemiology*
  • Diabetes Mellitus, Type 1 / prevention & control
  • Female
  • Glutens / adverse effects*
  • Humans
  • Italy / epidemiology
  • Male
  • Prevalence
  • Prospective Studies
  • Thyroiditis, Autoimmune / epidemiology*
  • Thyroiditis, Autoimmune / prevention & control

Substances

  • Glutens