[Hemoglobin A1C Determination and Hemoglobinopathies: Problems and Strategies]

Ann Biol Clin (Paris). Jul-Aug 2000;58(4):425-9.
[Article in French]


The semiological value of hemoglobin A1c (HbA1c) as a retrospective and cumulative marker of glycemic balance in diabetic patients is greatly weakened in case of hemoglobinopathy. The presence of an abnormal hemoglobin raises methodological problems due to the interferences generated in most assay methods, but also alters the normal process of HbA glycation to HbA1c, and often induces a certain level of hemolysis, very variable and impossible to quantify. This paper reviews methodological and semiological problems related to the presence of abnormal hemoglobin species, and proposes a standardized strategy in case of hemoglobinopathies.

Publication types

  • Review

MeSH terms

  • Artifacts
  • Blood Chemical Analysis / methods
  • Blood Glucose / metabolism*
  • Diabetes Mellitus / blood
  • Glycated Hemoglobin A / analysis*
  • Hemoglobinopathies / blood*
  • Hemolysis
  • Humans
  • Reproducibility of Results


  • Blood Glucose
  • Glycated Hemoglobin A