To the heart of myofibril assembly

Trends Cell Biol. 2000 Sep;10(9):355-62. doi: 10.1016/s0962-8924(00)01793-1.


One of the most fascinating examples of cytoskeletal assembly is the myofibril, the contractile structure of striated (i.e. skeletal and cardiac) muscle. Myofibrils are composed of repeating contractile units known as sarcomeres, perhaps the most highly ordered macromolecular structures in eukaryotic cells. When skeletal and cardiac muscle cells differentiate, thousands of structural and regulatory molecules assemble into the semicrystalline sarcomeric contractile units. As a consequence of this precise assembly, many different classes of proteins function together to convert the molecular interactions of actin and myosin efficiently into the macroscopic movements of contractile activity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Muscle, Skeletal / cytology*
  • Muscle, Skeletal / metabolism*
  • Myocardium / cytology*
  • Myocardium / metabolism*
  • Myofibrils / metabolism*