The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs

Nat Genet. 2000 Aug;25(4):381-4. doi: 10.1038/78051.


In model organisms, chemical mutagenesis provides a powerful alternative to natural, polygenic variation (for example, quantitative trait loci (QTLs)) for identifying functional pathways and complex disease genes. Despite recent progress in QTLs, we expect that mutagenesis is will ultimately prove more effective because the prospects of gene identification are high and every gene affecting a trait is potentially a target.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Female
  • Genes / genetics*
  • Genetic Variation*
  • Humans
  • Linkage Disequilibrium
  • Male
  • Mutagenesis
  • Phenotype
  • Quantitative Trait, Heritable