Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

Nat Med. 2000 Aug;6(8):849-51. doi: 10.1038/78592.

Abstract

Cells from the telomerase knockout mouse immortalize with an approximately ten million-fold greater frequency than human cells. In this commentary, Wright and Shay discuss the implications of this difference between mice and men and its relationship to cancer.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Division
  • Cellular Senescence
  • Fibroblasts / cytology
  • Humans
  • Mice
  • Mice, Knockout
  • Neoplasms / etiology*
  • Neoplasms / prevention & control*
  • Species Specificity
  • Telomerase / genetics
  • Telomerase / physiology
  • Telomere / physiology*

Substances

  • Telomerase