AIDS myelopathy is not associated with elevated HIV viral load in cerebrospinal fluid

Neurology. 2000 Aug 8;55(3):440-2. doi: 10.1212/wnl.55.3.440.


The pathogenesis of AIDS-associated myelopathy is unknown. Elevated HIV-1 viral load in CSF has been associated with cognitive impairment. The authors investigated if a similar association exists in patients with myelopathy. The authors evaluated levels of HIV-1 RNA in the CSF of 16 individuals with AIDS myelopathy and in 16 nonmyelopathic HIV-infected control subjects. There was no correlation between levels of HIV-1 RNA and the presence or severity of myelopathy.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acquired Immunodeficiency Syndrome / cerebrospinal fluid*
  • Acquired Immunodeficiency Syndrome / virology
  • Adult
  • Female
  • HIV-1 / genetics
  • HIV-1 / isolation & purification*
  • Humans
  • Male
  • Middle Aged
  • RNA, Viral / cerebrospinal fluid
  • Severity of Illness Index
  • Spinal Cord Diseases / cerebrospinal fluid*
  • Spinal Cord Diseases / virology*
  • Tumor Necrosis Factor-alpha / cerebrospinal fluid
  • Viral Load*


  • RNA, Viral
  • Tumor Necrosis Factor-alpha