The CD28-related molecule ICOS is required for effective T cell-dependent immune responses

Immunity. 2000 Jul;13(1):95-105. doi: 10.1016/s1074-7613(00)00011-x.


While CD28 is critical for expansion of naive T cells, recent evidence suggests that the activation of effector T cells is largely independent of CD28/B7. We suggest that ICOS, the third member of the CD28/CTLA-4 family, plays an important role in production of IL-2, IL-4, IL-5, and IFNgamma from recently activated T cells and contributes to T cell-dependent B help in vivo. Inhibition of ICOS attenuates lung mucosal inflammation induced by Th2 but not Th1 effector populations. Our data indicate a critical function for the third member of the CD28 family in T cell-dependent immune responses.

MeSH terms

  • Abatacept
  • Animals
  • Antigens, CD
  • Antigens, Differentiation / immunology
  • Antigens, Differentiation, T-Lymphocyte / genetics
  • Antigens, Differentiation, T-Lymphocyte / immunology*
  • CD28 Antigens / immunology*
  • CTLA-4 Antigen
  • Cloning, Molecular
  • Cytokines / biosynthesis
  • Gene Expression
  • Humans
  • Immunoconjugates*
  • Immunoglobulin G / biosynthesis
  • Immunoglobulin M / biosynthesis
  • Inducible T-Cell Co-Stimulator Protein
  • Jurkat Cells
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Transgenic
  • Signal Transduction
  • Th1 Cells / immunology*
  • Th2 Cells / immunology*


  • Antigens, CD
  • Antigens, Differentiation
  • Antigens, Differentiation, T-Lymphocyte
  • CD28 Antigens
  • CTLA-4 Antigen
  • CTLA4 protein, human
  • Ctla4 protein, mouse
  • Cytokines
  • ICOS protein, human
  • Icos protein, mouse
  • Immunoconjugates
  • Immunoglobulin G
  • Immunoglobulin M
  • Inducible T-Cell Co-Stimulator Protein
  • Abatacept