In vitro antibiotic susceptibility of Francisella tularensis isolated from humans and animals

J Antimicrob Chemother. 2000 Aug;46(2):287-90. doi: 10.1093/jac/46.2.287.


The in vitro susceptibility of 38 strains of Francisella tularensis (biovar F. tularensis palaearctica) was determined using Etests on cysteine heart agar plates with 2% haemoglobin. All strains were susceptible to the antibiotics traditionally used to treat tularaemia, such as streptomycin (MIC(90) 4.0 mg/L), tetracycline (MIC(90) 0.38 mg/L) and chloramphenicol (MIC(90) 0.38 mg/L), and to aminoglycosides, such as tobramycin (MIC(90) 1.5 mg/L) and gentamicin (MIC(90) 1.0 mg/L). The quinolones examined had low MIC(90)s: ciprofloxacin, 0.016 mg/L; levofloxacin, 0.016 mg/L; grepafloxacin, 0.047 mg/L; and trovafloxacin, 0.032 mg/L. In contrast, all the strains were resistant to beta-lactams and azithromycin. Quinolones thus seem to be promising drugs for the treatment of tularaemia.

MeSH terms

  • Animals
  • Animals, Wild / microbiology*
  • Anti-Bacterial Agents / pharmacology*
  • Arvicolinae
  • DNA, Bacterial / analysis
  • DNA, Bacterial / isolation & purification
  • Electrophoresis, Polyacrylamide Gel
  • Francisella tularensis / drug effects*
  • Humans
  • Microbial Sensitivity Tests
  • Rabbits
  • Reverse Transcriptase Polymerase Chain Reaction
  • Tularemia / microbiology*


  • Anti-Bacterial Agents
  • DNA, Bacterial