Neurotrophins and the dynamic regulation of the neuronal cytoskeleton

J Neurobiol. 2000 Aug;44(2):159-73. doi: 10.1002/1097-4695(200008)44:2<159::aid-neu6>;2-h.


The morphology of neuronal axons and dendrites is dependent on the dynamics of the cytoskeleton. An understanding of neurodevelopment and adult neuroplasticity must therefore include a detailed description of the intrinsic and extrinsic mechanisms that regulate the organization and dynamics of actin filaments and microtubules. In this paper we review recent advances in the understanding of the dynamic regulation of neuronal morphology by interactions among cytoskeletal components and the regulation of the cytoskeleton by neurotrophins.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cytoskeleton / physiology*
  • Growth Cones / physiology*
  • Nerve Growth Factors / physiology*


  • Nerve Growth Factors