The nuclear import function of Smad2 is masked by SARA and unmasked by TGFbeta-dependent phosphorylation

Nat Cell Biol. 2000 Aug;2(8):559-62. doi: 10.1038/35019649.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Motifs
  • Amino Acid Sequence
  • Biological Transport / drug effects
  • Carrier Proteins / metabolism*
  • Cell Membrane Permeability / drug effects
  • Cell Nucleus / drug effects
  • Cell Nucleus / metabolism*
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Digitonin / pharmacology
  • HeLa Cells
  • Humans
  • Immunohistochemistry
  • Intracellular Signaling Peptides and Proteins*
  • Phosphorylation / drug effects
  • Protein Binding / drug effects
  • Protein Structure, Tertiary
  • Recombinant Fusion Proteins / chemistry
  • Recombinant Fusion Proteins / metabolism
  • Sequence Deletion
  • Serine Endopeptidases*
  • Smad2 Protein
  • Trans-Activators / chemistry
  • Trans-Activators / genetics
  • Trans-Activators / metabolism*
  • Transfection
  • Transforming Growth Factor beta / pharmacology*

Substances

  • Carrier Proteins
  • DNA-Binding Proteins
  • Intracellular Signaling Peptides and Proteins
  • Recombinant Fusion Proteins
  • SMAD2 protein, human
  • Smad2 Protein
  • Trans-Activators
  • Transforming Growth Factor beta
  • ZFYVE16 protein, human
  • Serine Endopeptidases
  • Digitonin