Effect of dietary fiber on intraluminal pressure and myoelectrical activity of left colon in monkeys

Gastroenterology. 1979 Jul;77(1):70-4.


The effects of varying intake of dietary fiber content on left colon intraluminal pressure, electrical spike discharge activity, and contractions of circular muscle were measured in stump-tailed monkeys. Animals were preconditioned to sit in restraint chairs and then had the sigmoid colon instrumented with an extraluminal strain gage force transducer, a bipolar serosal electrode and a Thomas cannula to provide access for determining luminal pressure with a perfused, open-tip catheter. Diets containing 0, 5, 10, 15, and 20 g of dietary fiber daily were fed in varying sequences for periods of 3 wk. Observations were made twice during the last week of each diet. Fecal weight increased in animals on a high fiber diet, but changing dietary fiber content did not alter the duration of spike discharge activity and produced only a minimal change in the contraciton frequency of colon circular muscle. Colon intraluminal pressure was increased significantly by feeding low-fiber diets, but intraluminal pressure responses did not always correlate with the myoelectrical activity of the colon circular muscle.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cellulose / metabolism*
  • Colon / physiology*
  • Diet
  • Dietary Fiber / metabolism*
  • Electrophysiology
  • Feces
  • Haplorhini
  • Macaca
  • Muscle Contraction
  • Muscle, Smooth / physiology
  • Pressure


  • Dietary Fiber
  • Cellulose