Inheritance of pendulum movements in rats

Behav Genet. 2000 Jan;30(1):77-81. doi: 10.1023/a:1002094728510.


The stereotyped hyperkinesis referred to as pendulum movements (PM) may be found in up to 50% of the animals in stocks of Wistar rats. The mode of inheritance of predisposition to PM was studied by two methods: 1) a classical Mendelian analysis of hybrids of the strains PM+ and PM- bred from Wistar stock for enhancement and absence of PM, respectively, and 2) a segregation analysis of pedigree data from the archive records of breeding the cataleptic GC strain. The two methods gave the same result: the inheritance of predisposition to PM can be explained by a major gene model with an incomplete penetrance of heterozygous genotype.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Female
  • Genetic Carrier Screening
  • Genotype*
  • Male
  • Models, Genetic
  • Rats
  • Rats, Wistar
  • Selection, Genetic
  • Stereotyped Behavior / physiology*