ADAMTS9, a novel member of the ADAM-TS/ metallospondin gene family

Genomics. 2000 Aug 1;67(3):343-50. doi: 10.1006/geno.2000.6246.


ADAM-TS/metallospondin genes encode a new family of proteins with structural homology to the ADAM metalloprotease-disintegrin family. However, unlike other ADAMs, these proteins contain thrombospondin type 1 (TSP1) repeats at the carboxy-terminal end and are secreted proteins instead of being membrane bound. Members of the ADAM-TS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and the inhibition of angiogenesis. We have cloned a new member of the ADAM-TS/metallospondin family designated here as ADAMTS9. This protein has a metalloprotease domain, a disintegrin-like domain, one internal TSP1 motif, and three carboxy-terminal TSP1-like submotifs. In contrast to other ADAM-TS family members, ADAMTS9 is expressed in all fetal tissues examined as well as some adult tissues. Using FISH and radiation hybrid analysis, we have localized ADAMTS9 to chromosome 3p14.2-p14.3, an area known to be lost in hereditary renal tumors.

MeSH terms

  • ADAM Proteins
  • ADAMTS9 Protein
  • Amino Acid Sequence
  • Animals
  • Chromosome Mapping
  • Chromosomes, Human, Pair 3 / genetics*
  • Cloning, Molecular
  • DNA Primers / chemistry
  • Disintegrins / genetics*
  • Disintegrins / metabolism
  • Gene Expression
  • Humans
  • In Situ Hybridization, Fluorescence
  • Metalloendopeptidases / genetics*
  • Molecular Sequence Data
  • Rats
  • Reverse Transcriptase Polymerase Chain Reaction
  • Thrombospondins / genetics*
  • Thrombospondins / metabolism


  • DNA Primers
  • Disintegrins
  • Thrombospondins
  • ADAM Proteins
  • ADAMTS9 Protein
  • ADAMTS9 protein, human
  • Metalloendopeptidases