Gene therapy of cancer with interferon: lessons from tumor models and perspectives for clinical applications

Semin Cancer Biol. 2000 Apr;10(2):145-57. doi: 10.1006/scbi.2000.0333.


Cytokine gene transfer is a current approach in studies of gene therapy of cancer IFNs represent valuable cytokines for these studies, since they exert multiple biological effects, including anti-tumor activities. Early studies have been focused on IFN-gamma. Recently, several reports have shown that the transfer of type I IFN (especially IFN-alpha) genes represents a powerful approach for inducing tumor suppression. Recent studies have underscored new IFN-induced activities on immune cells. This knowledge adds a further rationale for the use of IFN-alpha in strategies of gene therapy of cancer and can be exploited for the design of more selective and effective anticancer treatments.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Gene Transfer Techniques
  • Genetic Engineering
  • Genetic Therapy*
  • Humans
  • Interferons / genetics
  • Interferons / therapeutic use*
  • Neoplasms / therapy*


  • Interferons