Traumatic brain injury as a risk factor for Alzheimer's disease: a review

Neuropsychol Rev. 2000 Jun;10(2):115-29. doi: 10.1023/a:1009068804787.


Accumulating epidemiological evidence implicates traumatic brain injury as a pathogenic agent in the development of Alzheimer's disease (AD). Considering the increase in the prevalence of both traumatic brain injury and AD in recent times, the possibility that brain trauma may provoke the early development of AD has important implications for health service planning, preventative efforts, and medico-legal compensation settlements. This paper evaluates the plausibility of the proposed link between traumatic brain injury and AD, largely by way of exploring a theoretical perspective advanced by Satz (1993) and considering recent contributions from the epidemiological, neuropathological, and biochemical literature that are pertinent to this issue. The literature reviewed provides sufficient support and empirical vindication to give credence to the proposed association between these two neuropsychological entities at the statistical, theoretical, and biological level.

Publication types

  • Review

MeSH terms

  • Age of Onset
  • Alzheimer Disease / epidemiology
  • Alzheimer Disease / etiology*
  • Alzheimer Disease / genetics
  • Brain / pathology
  • Brain / physiopathology*
  • Brain Injuries / complications*
  • Brain Injuries / epidemiology
  • Brain Injuries / physiopathology
  • Cohort Studies
  • Europe / epidemiology
  • Genetic Predisposition to Disease
  • Humans
  • Incidence
  • Meta-Analysis as Topic
  • Minnesota / epidemiology
  • Models, Neurological
  • Odds Ratio
  • Risk Factors
  • Trauma Severity Indices
  • United States / epidemiology