Ancestrally-duplicated paraHOX gene clusters in humans

Int J Oncol. 2000 Sep;17(3):439-44. doi: 10.3892/ijo.17.3.439.


A paraHox gene cluster has been described recently in Amphioxus. We show here using bioinformatics and cytogenetics that, as the probable result of the duplication of an ancestral paraHox gene cluster, human paraHOX genes are located in four paralogous regions of the genome, on chromosomes 4, 5, 13 and X. By analogy with the four HOX gene clusters, we propose to designate the four paraHOX gene clusters as paraHOX-A to D clusters. We also propose a scenario for the evolution of HOX and paraHOX genes. Several chromosomal translocation breakpoints of hemopathies are located in the paralogous regions that contain the paraHOX genes. Two of the paraHOX genes are involved in these rearrangements.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chromosome Mapping
  • Chromosomes, Human / genetics*
  • Chromosomes, Human, Pair 13 / genetics
  • Chromosomes, Human, Pair 4 / genetics
  • Chromosomes, Human, Pair 5 / genetics
  • Evolution, Molecular*
  • Expressed Sequence Tags
  • Gene Duplication*
  • Genes, Homeobox*
  • Humans
  • In Situ Hybridization, Fluorescence
  • Invertebrates / genetics
  • Mice
  • Molecular Sequence Data
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Species Specificity
  • Translocation, Genetic
  • Vertebrates / genetics
  • X Chromosome / genetics