Free radicals in chronic fatigue syndrome: cause or effect?

Redox Rep. 2000;5(2-3):146-7. doi: 10.1179/135100000101535519.

Abstract

We have demonstrated that certain morphological and biochemical changes occur in chronic fatigue syndrome (CFS) and in rheumatoid arthritis (RA). These changes in RA can be explained by the well-established inappropriate increase in free radical generation. The similar changes in CFS suggest a similar explanation and a possible role for free radicals in the aetiology of this condition.

MeSH terms

  • 2,3-Diphosphoglycerate / blood
  • Arthritis, Rheumatoid / blood
  • Erythrocytes / metabolism*
  • Erythrocytes / ultrastructure
  • Fatigue Syndrome, Chronic / blood*
  • Female
  • Free Radicals / blood
  • Glutathione / blood
  • Humans
  • Male
  • Malondialdehyde / blood
  • Methemoglobin / metabolism

Substances

  • Free Radicals
  • 2,3-Diphosphoglycerate
  • Malondialdehyde
  • Methemoglobin
  • Glutathione