An evaluation of Coffea cruda effect on rats

Br Homeopath J. 2000 Jul;89(3):122-6. doi: 10.1038/sj.bhj.5800417.


To investigate the effect of the homeopathic medicine Coffea cruda on sleep pattern, it was orally administered to rats at the beginning of their waking period. EEG from the parietal region was recorded during their next sleep cycle. Applying an FFT algorithm, spectral in the delta band, 0.5-2.5 Hz, was chosen as a marker parameter, evaluated for control and verum groups using a double-blind protocol. Power in the verum group was statistically higher than baseline value, it was not statistically different in the control group. The results indicate that an enhancement in EEG slow delta activity is associated with Coffea cruda.

MeSH terms

  • Administration, Oral
  • Animals
  • Central Nervous System Stimulants / administration & dosage
  • Central Nervous System Stimulants / pharmacology*
  • Coffee*
  • Double-Blind Method
  • Electroencephalography / drug effects
  • Homeopathy
  • Male
  • Phytotherapy
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology
  • Rats
  • Rats, Wistar
  • Sleep / drug effects*
  • Sleep Initiation and Maintenance Disorders / physiopathology


  • Central Nervous System Stimulants
  • Coffee
  • Plant Extracts