Anti-tumor-promoting activity of lignans from the aerial part of Saussurea medusa

Cancer Lett. 2000 Sep 29;158(1):53-9. doi: 10.1016/s0304-3835(00)00499-7.


In the course of our continuing search for novel cancer chemopreventive agents from natural sources, several kinds of Compositae plants were screened. Consequently, the lignans, arctiin (ARC) and arctigenin (ARC-G), were obtained from the aerial part of Saussurea medusaas active constituents. These compounds exhibited the remarkable anti-tumor-promoting effect on two-stage carcinogenesis test of mouse skin tumors induced by 7, 12-dimethylbenz[a]anthracene as an initiator and 12-O-tetradecanoyl phorbol-13-acetate as a promoter by both topical application and oral administration. Furthermore, ARC-G exhibited potent anti-tumor-promoting activity on two-stage carcinogenesis test of mouse pulmonary tumors induced by 4-nitroquinoline-N-oxide as an initiator and glycerol as a promoter.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Nitroquinoline-1-oxide
  • 9,10-Dimethyl-1,2-benzanthracene
  • Administration, Oral
  • Administration, Topical
  • Animals
  • Antineoplastic Agents, Phytogenic / therapeutic use*
  • Asteraceae / chemistry*
  • Cells, Cultured
  • Disease Models, Animal
  • Female
  • Glycerol
  • Lignans / therapeutic use*
  • Lung Neoplasms / chemically induced
  • Lung Neoplasms / drug therapy*
  • Mice
  • Mice, Inbred ICR
  • Mice, Inbred SENCAR
  • Neoplasm Transplantation
  • Phytotherapy*
  • Skin Neoplasms / chemically induced
  • Skin Neoplasms / drug therapy*
  • Tetradecanoylphorbol Acetate


  • Antineoplastic Agents, Phytogenic
  • Lignans
  • 4-Nitroquinoline-1-oxide
  • 9,10-Dimethyl-1,2-benzanthracene
  • Tetradecanoylphorbol Acetate
  • Glycerol