Selamectin: a novel broad-spectrum endectocide for dogs and cats

Vet Parasitol. 2000 Aug 23;91(3-4):163-76. doi: 10.1016/s0304-4017(00)00289-2.

Abstract

Selamectin, 25-cyclohexyl-25-de(1-methylpropyl)-5-deoxy-22, 23-dihydro-5-(hydroxyimino)-avermectin B1 monosaccharide, is a novel endectocide with a unique combination of efficacy and safety in dogs and cats following both oral and topical administration. The compound is active against fleas and ticks, intestinal hookworms and ascarids, and immature heartworms. Also it is well tolerated at higher dosages than 22,23-dihydroavermectin B1a (DHAVM) or milbemycin oxime in Collies, which is a breed known to exhibit idiosyncratic sensitivity to avermectins.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Animals
  • Antiparasitic Agents / administration & dosage*
  • Antiparasitic Agents / therapeutic use*
  • Cat Diseases / drug therapy*
  • Cats
  • Dog Diseases / drug therapy*
  • Dogs
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Ectoparasitic Infestations / drug therapy
  • Ectoparasitic Infestations / veterinary*
  • Female
  • Ivermectin / analogs & derivatives*
  • Ivermectin / therapeutic use
  • Male
  • Siphonaptera / drug effects*

Substances

  • Antiparasitic Agents
  • Ivermectin
  • selamectin