The biochemical effect of coriander seeds on lipid parameters in 1,2-dimethyl hydrazine (DMH) induced colon cancer in rats were studied. The study shows that the concentrations of cholesterol and cholesterol to phospholipid ratio decreased while the level of phospholipid increased significantly in the DMH control group compared to the spice administered group. Fecal dry weight, fecal neutral sterols and bile acids showed a sharp increase in the coriander-fed group compared with the DMH administered group. Thus, coriander plays a protective role against the deleterious effects in lipid metabolism in experimental colon cancer.