Abstract
T-box genes encode transcription factors that regulate many developmental processes. We have cloned a novel mouse T-box gene, Tbx12. Tbx12 is the vertebrate homologue of the Drosophila H15 gene and the Caenorhabditis elegans tbx-12 gene. Tbx12 is expressed in extraembryonic tissues such as the amnion and allantois. In the embryo, Tbx12 is strongly expressed in the neural retina and the heart.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Allantois / metabolism
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Amino Acid Sequence
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Amnion / metabolism
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Animals
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Base Sequence
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Caenorhabditis elegans / embryology
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Chromosome Mapping
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Cloning, Molecular
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DNA, Complementary / metabolism
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DNA-Binding Proteins
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Drosophila / embryology
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Embryo, Mammalian / metabolism
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Embryo, Nonmammalian
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Heart / embryology*
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In Situ Hybridization
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Mice
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Molecular Sequence Data
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Phylogeny
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Retina / embryology*
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T-Box Domain Proteins*
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Time Factors
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Transcription Factors / biosynthesis*
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Transcription Factors / genetics
Substances
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DNA, Complementary
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DNA-Binding Proteins
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T-Box Domain Proteins
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Tbx20 protein, mouse
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Transcription Factors