Tbx12, a novel T-box gene, is expressed during early stages of heart and retinal development

Mech Dev. 2000 Aug;96(1):137-40. doi: 10.1016/s0925-4773(00)00376-2.

Abstract

T-box genes encode transcription factors that regulate many developmental processes. We have cloned a novel mouse T-box gene, Tbx12. Tbx12 is the vertebrate homologue of the Drosophila H15 gene and the Caenorhabditis elegans tbx-12 gene. Tbx12 is expressed in extraembryonic tissues such as the amnion and allantois. In the embryo, Tbx12 is strongly expressed in the neural retina and the heart.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allantois / metabolism
  • Amino Acid Sequence
  • Amnion / metabolism
  • Animals
  • Base Sequence
  • Caenorhabditis elegans / embryology
  • Chromosome Mapping
  • Cloning, Molecular
  • DNA, Complementary / metabolism
  • DNA-Binding Proteins
  • Drosophila / embryology
  • Embryo, Mammalian / metabolism
  • Embryo, Nonmammalian
  • Heart / embryology*
  • In Situ Hybridization
  • Mice
  • Molecular Sequence Data
  • Phylogeny
  • Retina / embryology*
  • T-Box Domain Proteins*
  • Time Factors
  • Transcription Factors / biosynthesis*
  • Transcription Factors / genetics

Substances

  • DNA, Complementary
  • DNA-Binding Proteins
  • T-Box Domain Proteins
  • Tbx20 protein, mouse
  • Transcription Factors