Meta-analysis of diagnostic tests for acute sinusitis

J Clin Epidemiol. 2000 Aug;53(8):852-62. doi: 10.1016/s0895-4356(00)00209-2.


To facilitate management of acute sinusitis, we conducted a meta-analysis of published studies comparing diagnostic tests for this disorder. Thirteen studies were identified through literature search. Based on sinus puncture/aspiration (considered most accurate), 49-83% of symptomatic patients had acute sinusitis. Compared with puncture/aspiration, radiography offered moderate ability to diagnose sinusitis (summary receiver operator curve [SROC] area, 0.83). Using sinus opacity or fluid as the criterion for sinusitis, radiography had sensitivity of 0.73 and specificity of 0.80. Studies evaluating ultrasonography revealed substantial variation in test performance. The clinical evaluation, particularly risk scores formally incorporating history and physical examination findings, had moderate ability to identify patients with positive radiographs (SROC area, 0.74). Many studies were of poor quality, with inadequately described test methods and unblinded test interpretation. In conclusion, acute sinusitis is common among symptomatic patients. Radiography and clinical evaluation (especially risk scores) appear to provide useful information for diagnosis of sinusitis.

Publication types

  • Comparative Study
  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acute Disease
  • Adolescent
  • Adult
  • Aged
  • Biopsy, Needle / standards
  • Child
  • Female
  • Humans
  • Male
  • Middle Aged
  • Paranasal Sinuses / diagnostic imaging
  • Paranasal Sinuses / pathology
  • Physical Examination / standards*
  • ROC Curve
  • Radiography
  • Sensitivity and Specificity
  • Sinusitis / diagnosis*
  • Sinusitis / diagnostic imaging
  • Ultrasonography