Cold Shock Response in Bacillus Subtilis

J Mol Microbiol Biotechnol. 1999 Nov;1(2):203-9.


Following a rapid decrease in temperature, the physiology of Bacillus subtilis cells changes profoundly. Cold shock adaptation has been monitored at the level of membrane composition, adjustment in DNA topology, and change in cytosolic protein synthesis/composition. Some major players in these processes (cold-stress induced proteins and cold acclimatization proteins, CIPs and CAPs) have been identified and mechanisms in cold shock acclimatization begin to emerge; however, important questions regarding their cellular function still need to be answered.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacillus / physiology
  • Bacillus subtilis / genetics
  • Bacillus subtilis / metabolism
  • Bacillus subtilis / physiology*
  • Bacterial Proteins / physiology
  • Cell Membrane / metabolism
  • Cell Membrane / physiology
  • Chromosomes, Bacterial
  • Cold Temperature*
  • Cytosol / metabolism
  • Heat-Shock Proteins / physiology
  • Isomerases / metabolism
  • Molecular Chaperones / metabolism
  • Protein Folding
  • RNA, Bacterial / metabolism


  • Bacterial Proteins
  • Heat-Shock Proteins
  • Molecular Chaperones
  • RNA, Bacterial
  • Isomerases