The authors describe current investigation and most recent developments in three areas of pediatrics commonly faced by the office practitioner. The impetus of earlier newborn discharge places increased emphasis on pediatricians to accurately predict clinically significant jaundice. A better understanding of the pathophysiology of breastfeeding and breast milk jaundice, and the realization that Gilbert's syndrome may play a greater role in neonatal jaundice, only help confirm that the story of neonatal jaundice is still unfolding. Animal (particularly canine) bite injuries continue to be the most common animal-induced injuries, and a thorough review of appropriate antibiotic treatment and rabies prophylaxis guidelines are essential for the pediatric practitioner. During the past year, several major changes involving the use of rotavirus, pneumococcal, polio, meningococcal, and hepatitis A vaccines have taken place, which will have marked impact not only on pediatric office practice, but also on society as a whole.