[Assessment of the somatotropic function of the hypophysis in patients with hypophyseal nanism and gonadal dysgenesis by using the insulin-tolerance and arginine-tolerance tests]

Probl Endokrinol (Mosk). 1975 Jan-Feb;21(1):30-8.
[Article in Russian]


With the aid of insulin-tolerance and arginine tolerance tests (ITT and ATT, respectively) somatotropic function of the hypophysis was assessed in 18 patients with hypophyseal nanism and in 12--with gonad dysgenesis. A marked delay in development and a premature exhaustion of the STH secretion was noted in the patients wiht hypophyseal nanism. In patients with gonad dysgenesis the STH secretion was somewhat redeced during the ITT. A change in the STH secretion was accompanied by a parallel depression of insulin secretion during the ATT. Patients with hypophyseal nanism displayed a correlation between the extent of growth delay and the value of the STH secretion during the ITT (R=0.6, P smaller than 0.05).

MeSH terms

  • Adolescent
  • Adult
  • Arginine
  • Blood Glucose / metabolism
  • Body Height
  • Dwarfism, Pituitary / physiopathology*
  • Female
  • Growth Hormone / metabolism*
  • Humans
  • Insulin / metabolism
  • Insulin Secretion
  • Islets of Langerhans / physiopathology
  • Pituitary Gland / physiopathology*
  • Time Factors
  • Turner Syndrome / physiopathology*


  • Blood Glucose
  • Insulin
  • Growth Hormone
  • Arginine