Regulation of cysteine-rich intestinal protein, a zinc finger protein, by mediators of the immune response
- PMID: 10944488
- DOI: 10.1086/315917
Regulation of cysteine-rich intestinal protein, a zinc finger protein, by mediators of the immune response
Abstract
Cysteine-rich intestinal protein (CRIP), a member of the LIM protein family, has a unique double zinc finger motif as the defining feature. CRIP is highly expressed in intestine and immune cells. CRIP transgenic (Tg) mice and nontransgenic controls were challenged with lipopolysaccharide (LPS). Serum concentrations of interferon-gamma and tumor necrosis factor-alpha were less while those of interleukin-6 and -10 were greater in the Tg mice following LPS administration. CRIP-overexpressing splenocytes produce the same cytokine profile. These responses are consistent with a regulatory role for this protein in cell differentiation, which produces an imbalance in Th1 and Th2 cytokines. Stimulation of CRIP protein levels by LPS is eliminated in metallothionein knockout mice, suggesting metallothionein is the source of zinc for this zinc finger protein and, further, that this could reflect a relationship to the zinc nutritional status and to the aberrant Th1/Th2 cytokine balance observed in zinc deficiency.
Similar articles
-
Overexpression of CRIP in transgenic mice alters cytokine patterns and the immune response.Am J Physiol Endocrinol Metab. 2002 Jun;282(6):E1197-203. doi: 10.1152/ajpendo.00508.2001. Am J Physiol Endocrinol Metab. 2002. PMID: 12006348
-
Constitutive expression of CIITA directs CD4 T cells to produce Th2 cytokines in the thymus.Cell Immunol. 2005 Jan;233(1):30-40. doi: 10.1016/j.cellimm.2005.03.006. Cell Immunol. 2005. PMID: 15876426
-
Structural characterization of the rat cysteine-rich intestinal protein gene and overexpression of this LIM-only protein in transgenic mice.DNA Cell Biol. 1998 Dec;17(12):1057-64. doi: 10.1089/dna.1998.17.1057. DNA Cell Biol. 1998. PMID: 9881673
-
Effects of histamine on Th1/Th2 cytokine balance.Int Immunopharmacol. 2003 Jul;3(7):909-20. doi: 10.1016/S1567-5769(02)00235-7. Int Immunopharmacol. 2003. PMID: 12810348 Review.
-
Cysteine-rich intestinal protein (CRIP): a new intestinal zinc transport protein.Nutr Rev. 1992 Aug;50(8):232-3. doi: 10.1111/j.1753-4887.1992.tb01334.x. Nutr Rev. 1992. PMID: 1407754 Review.
Cited by
-
CRIP1 involves the pathogenesis of multiple myeloma via dual-regulation of proteasome and autophagy.EBioMedicine. 2024 Feb;100:104961. doi: 10.1016/j.ebiom.2023.104961. Epub 2024 Jan 9. EBioMedicine. 2024. PMID: 38199044 Free PMC article.
-
EBV-Associated Hub Genes as Potential Biomarkers for Predicting the Prognosis of Nasopharyngeal Carcinoma.Viruses. 2023 Sep 12;15(9):1915. doi: 10.3390/v15091915. Viruses. 2023. PMID: 37766321 Free PMC article.
-
Inflammatory and tolerogenic myeloid cells determine outcome following human allergen challenge.J Exp Med. 2023 Sep 4;220(9):e20221111. doi: 10.1084/jem.20221111. Epub 2023 Jul 10. J Exp Med. 2023. PMID: 37428185 Free PMC article.
-
CRP‑1 promotes the malignant behavior of hepatocellular carcinoma cells via activating epithelial‑mesenchymal transition and Wnt/β‑catenin signaling.Exp Ther Med. 2023 May 12;26(1):314. doi: 10.3892/etm.2023.12013. eCollection 2023 Jul. Exp Ther Med. 2023. PMID: 37273753 Free PMC article.
-
Cysteine-Rich Intestinal Protein 1 Served as an Epithelial Ovarian Cancer Marker via Promoting Wnt/β-Catenin-Mediated EMT and Tumour Metastasis.Dis Markers. 2021 Aug 6;2021:3566749. doi: 10.1155/2021/3566749. eCollection 2021. Dis Markers. 2021. PMID: 34413913 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Miscellaneous
