Identification of novel polymorphisms in the AXIN1++ and CDX-2 genes

J Hum Genet. 2000;45(4):254-6. doi: 10.1007/s100380070036.


Axin and Cdx-2 play important roles in the tumorigenesis of human liver and colon. We have identified seven novel single-nucleotide polymorphisms (SNPs) in the AXIN1 gene and three in the CDX-2 gene. The identification of SNPs in these cancer-associated genes establishes a basis for future investigations to detect losses of heterozygosity in tumors; these SNPs may also provide genetic background information associated with cancer risk.

MeSH terms

  • Alleles
  • Axin Protein
  • CDX2 Transcription Factor
  • DNA Mutational Analysis
  • Exons
  • Genes, Tumor Suppressor*
  • Genotype
  • Homeodomain Proteins / genetics*
  • Humans
  • Japan
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide
  • Proteins / genetics*
  • Repressor Proteins*
  • Trans-Activators


  • AXIN1 protein, human
  • Axin Protein
  • CDX2 Transcription Factor
  • Homeodomain Proteins
  • Proteins
  • Repressor Proteins
  • Trans-Activators