Margin status and excision of cervical intraepithelial neoplasia: a review

Obstet Gynecol Surv. 2000 Aug;55(8):520-7. doi: 10.1097/00006254-200008000-00025.


Excisional biopsy of the cervix for diagnosis and treatment of cervical neoplasia is common. Management of patients with involved margins of resection is unresolved. Data concerning use of thermal techniques show that this technique yields equivalent results in most cases. Important exceptions are microinvasive squamous disease and adenocarcinoma. Conservative management of involved squamous margins is possible. Techniques for follow-up include cytology, colposcopy, and endocervical curettage. Adenocarcinoma in situ (AIS) should be treated with cold-knife conization. The standard of care for AIS is hysterectomy except in certain specific indications. Data concerning technique, follow-up, use of endocervical curettage, and the need for reexcision will be presented.

Target audience: Obstetricians & Gynecologists, Family Physicians.

Learning objectives: After completion of this article, the reader will be able to compare the efficacy of the various excisional procedures in the treatment of cervical dysplasia, list the indications for additional surgery after positive margins on cervical excisions, and describe the proper management of a patient with adenocarcinoma in situ.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biopsy
  • Conization / methods*
  • Electrosurgery / methods*
  • Female
  • Humans
  • Hysterectomy
  • Neoplasm Recurrence, Local / prevention & control*
  • Neoplasm, Residual / prevention & control*
  • Uterine Cervical Dysplasia / surgery*