Transverse myelitis associated with restless legs syndrome and periodic movements of sleep responsive to an oral dopaminergic agent but not to intrathecal baclofen

Sleep. 2000 Aug 1;23(5):591-4.

Abstract

Periodic limb movement disorder (PLMD) and restless legs syndrome (RLS) are related sleep disorders that occur with increased frequency in spinal cord disease. Effective treatment may be obtained with dopaminergic or opioid drugs, while anticonvulsants, benzodiazepines, and possibly baclofen may be helpful. This report describes a patient who developed RLS and PLMD after acute transverse myelitis associated with infectious mononucleosis, and failed to respond to intrathecal baclofen. All symptoms of RLS/PLMD resolved after treatment with pergolide.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Antiparkinson Agents / administration & dosage
  • Antiparkinson Agents / therapeutic use*
  • Baclofen / administration & dosage
  • Baclofen / therapeutic use*
  • Electromyography
  • Electrooculography
  • Humans
  • Injections, Spinal
  • Male
  • Middle Aged
  • Muscle Relaxants, Central / administration & dosage
  • Muscle Relaxants, Central / therapeutic use*
  • Myelitis, Transverse / complications*
  • Myelitis, Transverse / drug therapy*
  • Nocturnal Myoclonus Syndrome / diagnosis
  • Nocturnal Myoclonus Syndrome / drug therapy*
  • Nocturnal Myoclonus Syndrome / etiology*
  • Pergolide / administration & dosage
  • Pergolide / therapeutic use*
  • Polysomnography
  • Restless Legs Syndrome / diagnosis
  • Restless Legs Syndrome / drug therapy*
  • Restless Legs Syndrome / etiology*
  • Sleep, REM / physiology
  • Treatment Outcome

Substances

  • Antiparkinson Agents
  • Muscle Relaxants, Central
  • Pergolide
  • Baclofen