A review of the development of chicken lines to resolve genes determining resistance to diseases

Poult Sci. 2000 Aug;79(8):1082-93. doi: 10.1093/ps/79.8.1082.


The resolution of genes that determine resistance to disease is described using chicken lines maintained at the Avian Disease and Oncology Laboratory (ADOL). This description includes a summary 1) of existing selected and inbred lines differing for resistance to viral-induced tumors, i.e., Marek's disease (MD) and lymphoid leukosis (LL), and of the use of inbred and line crosses to define relevant disease-resistant genes, e.g., TV, ALVE, B, R, LY4, TH1, BU1, and IGG1; 2) of the development of TVB*/ALVE congenic lines to establish the affects of endogenous virus (EV) expression on resistance to avian leukosis virus (ALV), and methods to detect ALVE expression; 3) of the development of B congenic lines to define the influence of the MHC on MD resistance and vaccinal immunity, for producing B antisera, and for evaluating DNA sequences of Class I and II genes; and 4) of the current development of 6C.7 recombinant congenic strains (RCS) to define the role of non-MHC genes influencing susceptibility to MD and LL tumors, immune competence, and epistatic effects of genes. The procedures of pedigree mating, to avoid or maintain inbreeding, and of blood-typing, to ensure genetic purity of the lines, are also described.

Publication types

  • Review

MeSH terms

  • Animals
  • Breeding*
  • Chickens / genetics*
  • Disease Susceptibility / veterinary
  • Genetic Predisposition to Disease
  • Immunity, Innate / genetics*
  • Inbreeding
  • Tumor Virus Infections / genetics
  • Tumor Virus Infections / veterinary
  • Virus Diseases / genetics
  • Virus Diseases / veterinary