Mini-review: gephyrin, a major postsynaptic protein of GABAergic synapses

Eur J Neurosci. 2000 Jul;12(7):2205-10. doi: 10.1046/j.1460-9568.2000.00106.x.


gamma-aminobutyric acid type A (GABAA) receptors are located at the majority of inhibitory synapses in the mammalian brain. However, the mechanisms by which GABAA receptor subunits are targeted to, and clustered in, the postsynaptic membrane are poorly understood. Recent studies have demonstrated that gephyrin, a protein first identified as a component of the glycine receptor (GlyR) complex, is colocalized with several subtypes of GABAA receptors and is involved in the stabilization of postsynaptic GABAA receptor clusters. Thus, gephyrin functions as a clustering protein for major subtypes of inhibitory ion channel receptors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carrier Proteins / physiology*
  • Membrane Proteins / physiology*
  • Receptors, GABA-A / physiology*
  • Synapses / chemistry*
  • Synapses / physiology*
  • gamma-Aminobutyric Acid / physiology*


  • Carrier Proteins
  • Membrane Proteins
  • Receptors, GABA-A
  • gephyrin
  • gamma-Aminobutyric Acid