Giant cell arteritis and polymyalgia rheumatica: role of viral infections

Clin Exp Rheumatol. Jul-Aug 2000;18(4 Suppl 20):S22-3.


We performed a multicenter case-control study on incident cases of giant cell arteritis and polymyalgia, and tested for viruses known to induce multinucleated giant cells in human pathology. IgM directed against Human parainfluenza type 1 virus were shown to be significantly associated with the onset of the disease in 40% of the cases, versus 20% of the controls.

Publication types

  • Multicenter Study

MeSH terms

  • Antibodies, Viral / blood
  • Case-Control Studies
  • France / epidemiology
  • Giant Cell Arteritis / epidemiology*
  • Giant Cell Arteritis / virology*
  • Humans
  • Incidence
  • Parainfluenza Virus 1, Human*
  • Polymyalgia Rheumatica / epidemiology*
  • Polymyalgia Rheumatica / virology*
  • Respirovirus Infections / epidemiology*
  • Respirovirus Infections / immunology
  • Seroepidemiologic Studies


  • Antibodies, Viral