[Crohn disease, ulcerative colitis. When bacteria attack the intestinal wall...]

MMW Fortschr Med. 1999 Dec 16;141(51-52):48-51.
[Article in German]


Crohn's disease (CD) and ulcerative colitis (UC) are clinical entities characterized by spontaneous relapses and are thought to be caused in large part by a dysregulated immune response to inflammatory stimuli. Specific infectious agents or antigens inducing or perpetuating inflammation, however, are not known. Recent results in contrast support the hypothesis, that the normal intestinal flora plays a central role in the pathogenesis of both diseases. Studies performed with E. coli Nissle 1917 demonstrated that this bacterium can positively affect the course of disease in UC and CD patients. The clinical efficacy of probiotics can yield valuable information about disease pathogenesis and, as a modification of current standard therapy, opens new and interesting therapeutic alternatives.

Publication types

  • Review

MeSH terms

  • Colitis, Ulcerative / immunology
  • Colitis, Ulcerative / microbiology*
  • Colitis, Ulcerative / therapy
  • Crohn Disease / immunology
  • Crohn Disease / microbiology*
  • Crohn Disease / therapy
  • Escherichia coli*
  • Humans
  • Intestinal Mucosa / immunology
  • Intestinal Mucosa / microbiology*
  • Probiotics / therapeutic use
  • Recurrence