Autoantibody screening in subacute cerebellar ataxia

Lancet. 2000 Aug 12;356(9229):565-6. doi: 10.1016/S0140-6736(00)02585-X.


In a retrospective study of 280 sera from patients presenting with cerebellar signs, seven of whom had proved positive for the typical paraneoplastic serum antibodies that were requested by the clinicians, raised concentrations of antibodies to voltage-gated calcium channels or to glutamic acid decarboxylase were detected in a further seven sera. Systematic screening for these and other antibodies in future cases should help in the diagnosis and management of the patients.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autoantibodies / analysis*
  • Calcium Channels / immunology
  • Carcinoma, Small Cell / diagnosis
  • Carcinoma, Small Cell / immunology
  • Cerebellar Ataxia / immunology*
  • Glutamate Decarboxylase / immunology
  • Humans
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / immunology
  • Paraneoplastic Syndromes / immunology*
  • Retrospective Studies


  • Autoantibodies
  • Calcium Channels
  • Glutamate Decarboxylase